2010 Western & Southern Financial Group Masters – Singles
| Singles | |
|---|---|
| 2010 Western & Southern Financial Group Masters | |
| Champion |
 Roger Federer
|
| Runner-up |
 Mardy Fish
|
| Final score | 6–7(5–7), 7–6(7–1), 6–4 |
Roger Federer became the first player since Andre Agassi in 1996 to have successfully defended the title. He defeated Mardy Fish in the final 6–7(5), 7–6(1), 6–4. It was his 4th win at the event also winning in 2005, 2007, and 2009. It was also Federer's 17th Masters win putting him level with Agassi and his 63rd title putting him on par with Björn Borg.
The top eight seeds receive a bye into the second round.
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