2010 Sony Ericsson Open – Women's Singles
| Women's Singles | |
|---|---|
| 2010 Sony Ericsson Open | |
| Champion |
 Kim Clijsters
|
| Runner-up |
 Venus Williams
|
| Final score | 6–2, 6–1 |
Victoria Azarenka was the defending champion, but lost to Kim Clijsters in the fourth round.
Clijsters won her second title in Miami by defeating Venus Williams in straight sets.
All seeds receive a bye into the second round.
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