2010 Sony Ericsson Open – Men's Singles
| Men's Singles | |
|---|---|
| 2010 Sony Ericsson Open | |
| Champion |
 Andy Roddick
|
| Runner-up |
 Tomáš Berdych
|
| Final score | 7–5, 6–4 |
Andy Murray was the defending champion, but lost to Mardy Fish in the second round.
Andy Roddick beat Tomáš Berdych 7–5, 6–4 to win his first Masters 1000 event since 2006. It was his second title at the Sony Ericsson Open and his second title of 2010.
All seeds receive a bye into the second round.
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