The 2010 National League Division Series (NLDS) were two best-of-five game series to determine the participating teams in the 2010 National League Championship Series. The three divisional winners and a fourth team—a "Wild Card"—played in two series from October 6 to 11. TBS televised all games in the United States.

Under MLB's playoff format, no two teams from the same division were matched up in the Division Series, regardless of whether their records would normally indicate such a matchup. Home field advantage went to the team with the better regular-season record with the exception of the wild card team, which defers home field advantage regardless of record. The matchups were:

The Phillies and Reds had met in the postseason once before: in the 1976 NLCS, which the Reds won 3–0. The Giants and Braves also had one prior postseason series—the 2002 NLDS—which the Giants won 3–2.

Philadelphia won the series, 3–0.

†: No-hitter by Roy Halladay

San Francisco won the series, 3–1.

5:00 p.m. (EDT) at Citizens Bank Park in Philadelphia, Pennsylvania

In his first career postseason start, Phillies ace Roy Halladay hurled a no-hitter, giving up only one walk (to Jay Bruce in the fifth inning). Halladay's was only the second postseason no-hitter in Major League Baseball history, and the first since Don Larsen's perfect game in the 1956 World Series. He threw only 104 pitches.

During the 2010 regular season, Halladay had thrown a perfect game on the road against the Florida Marlins on May 29. He thus became the first and only pitcher to throw a no-hitter in the regular season and a no-hitter in the postseason in the same year. Halladay is also the fifth major league pitcher to throw two no-hitters in the same year, and the first since Nolan Ryan in 1973.

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