The 2010 National League Championship Series (NLCS) was a best-of-seven game Major League Baseball playoff series that pitted the winners of the 2010 National League Division Series—Philadelphia Phillies and San Francisco Giants—against each other for the National League Championship. The Giants won the series 4–2 and went on to win the 2010 World Series. The series, the 41st in league history, began on October 16 and ended on October 23. The Phillies had home field advantage as a result of their better regular-season record. The Phillies hosted Games 1, 2 and 6, while the Giants were at home for Games 3, 4 and 5.

San Francisco won the series, 4–2.

Saturday, October 16, 2010 — 7:30 p.m. (EDT) at Citizens Bank Park in Philadelphia, Pennsylvania

In one of the most touted postseason pitching matchups in recent history, two former Cy Young Award winners faced off: Roy Halladay for the Phillies and Tim Lincecum for the Giants. The Giants jumped out to a 1–0 lead in the top of the third inning on a Cody Ross solo home run, Halladay's first hit allowed in the postseason. The Phillies quickly tied the game up in the bottom half of the same inning on a home run from catcher Carlos Ruiz.

The game remained tied until the top of the fifth inning, when Ross belted his second homer of the game, another solo shot, giving San Francisco a 2–1 lead. The Giants extended that lead to 4–1 the following inning on a string of three two-out hits, namely, a single by Buster Posey, a double by former Phillie Pat Burrell, and a single from Juan Uribe. In the bottom of the same inning, the sixth, the Phillies closed the deficit to 4–3 on a two-run blast from Jayson Werth.

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