2010 Big East football standings
	Conf				Overall
Team		W		L		W		L
Connecticut $+		5	–	2		8	–	5
West Virginia +		5	–	2		9	–	4
Pittsburgh +		5	–	2		8	–	5
Syracuse		4	–	3		8	–	5
South Florida		3	–	4		8	–	5
Louisville		3	–	4		7	–	6
Cincinnati		2	–	5		4	–	8
Rutgers		1	–	6		4	–	8

$ – BCS representative as conference champion + – Conference co-champions As of January 11, 2011; Rankings from AP Poll

The 2010 Louisville Cardinals football team represented the University of Louisville in the 2010 NCAA Division I FBS football season. The Cardinals were led by head coach Charlie Strong, who was in his first season. They played their home games at Papa John's Cardinal Stadium and were members of the Big East Conference. They finished the season 7–6, 3–4 in Big East play and were invited to the Beef 'O' Brady's Bowl, where they defeated Southern Miss, 31–28.