The 94th Indianapolis 500 was held at the Indianapolis Motor Speedway in Speedway, Indiana on Sunday May 30, 2010. It was the 15th Indy 500 sanctioned by the Indy Racing League, and was the premier event of the 2010 IZOD IndyCar Series season. The race was won by Dario Franchitti, ahead of Dan Wheldon and Marco Andretti. Tony Kanaan, who had started in the final position, ran as high as second during the race before finishing eleventh.

The race was the second of the three-year-long Centennial era, celebrating the 100th anniversary of the opening of the Indianapolis Motor Speedway and the 100th anniversary of the first Indianapolis 500. It was the 53rd time the race had been held on a May 30. This year marked the first race with four female drivers (repeated in 2011), and Simona de Silvestro was awarded Rookie of the Year.

The 2010 schedule was a two-week condensed schedule, but featured only one fewer day of on-track activity compared to 2009.

* Includes days where track activity
was significantly limited due to rain

ROP — denotes Rookie Orientation Program

Comm. Day — denotes 500 Festival Community Day

In the first hour of time trials, early runs filled the field to 33 cars. Several drivers put in safe speeds, including John Andretti, Alex Lloyd, Bruno Junqueira, and Sarah Fisher. A. J. Foyt IV parted ways with his grandfather's team and Jaques Lazier was drafted as his replacement.