2010 Heineken Open – Singles
| Singles | |
|---|---|
| 2010 Heineken Open | |
| Champion |
 John Isner
|
| Runner-up |
 Arnaud Clément
|
| Final score | 6–3, 5–7, 7–6(7–2) |
Juan Martín del Potro was the defending champion, but chose not to compete.
John Isner won in the final, 6–3, 5–7, 7–6(7–2), against Arnaud Clément.
The top four seeds receive a bye to the second round.
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