The 2010 East–West Shrine Game was the 85th staging of the all-star college football exhibition game featuring NCAA Division I Football Bowl Subdivision players. The game featured over 100 players from the 2009 college football season, and prospects for the 2010 Draft of the professional National Football League (NFL), as well as for the United Football League's inaugural draft. In the week prior to the game, scouts from all 32 NFL teams attended. The proceeds from the East-West Shrine Game benefit Shriners Hospitals for Children.

Marty Schottenheimer and Romeo Crennel served as the two teams' coaches for the game. The East team won by a 13–10 margin on the strength of a touchdown with just six seconds remaining. According to some reliable sources, Wisconsin defensive end O'Brien Schofield and Northwestern quarterback Mike Kafka of the east team were defensive and offensive MVPs, respectively. However, other sources point to East Carolina cornerback Van Eskridge also of the east team was selected as defensive MVP.