The 2010 Atlanta Tennis Championships was a tennis tournament played on outdoor hard courts. It was the 23rd edition of the event known that year as the Atlanta Tennis Championships and was part of the ATP World Tour 250 series of the 2010 ATP World Tour. The Atlanta Tennis Championships was the first ATP stop of the 2010 US Open Series.

2010 was the first year this tournament was held in Atlanta. Previously, it had been hosted by Indianapolis.

*Seedings based on the July 12, 2010 rankings and is subject to change.

The following players received wildcards into the singles main draw

The following players received entry from the qualifying draw:

Mardy Fish def. John Isner, 4–6, 6–4, 7–6^(7–4)

Scott Lipsky / Rajeev Ram def. Rohan Bopanna / Kristof Vliegen, 6–3, 6–7^(4–7), [12–10]