The 2010–11 Ukrainian Cup is the 20th annual season of Ukraine's football knockout competition, and third under the name of DATAGROUP – Football Ukraine Cup.

The Cup begins with two preliminary rounds, before the first round proper involving the Premier League clubs. The draw for the both preliminary rounds was held on July 14, 2010. The First Preliminary Round consists of teams from Druha Liha and Amateur Cup champions and has only five fixtures. In the Second Preliminary Round teams of the Persha Liha enter the competition. Sixteen teams, winners of the 2nd preliminary round enter the First Round or the Round of 32 where the Premier League teams enter the competition for the first time.

Tavriya Simferopol is the defending champion and as a member of the Premier League enter the competition at the Round of 32. Tavriya were eliminated in the Round of 32 by Dnipro Dnipropetrovsk 1–4. This season's winner enters the play-off round of the UEFA Europa League 2011–12.

This season's format for the main event has changed again. The announcement of the format was given during the draw of the round 32 in the headquarters of the FFU. All matches consist of a single game and would include extra time and series of penalties if necessary to identify a winner. The broadcast of the draw was officially conducted for the first time by one of the sponsors of the Ukrainian Premier League (Footballua).

The draw was blind. All participants were ranked according to their table standings on September 8, 2010 and listed in that order for the draw. All seeds of pairs were numerated such as the first pair consisted of number 1 and number 2, the second pair of number 3 and number 4, the third - 5 and 6, and so on. Clubs of a lower league when seeded with one from a higher would receive a home advantage. However, in case for the same league seeded clubs, the hosting club was identified by an odd number that was drawn upon calling its name. A former Soviet player Vadym Yevtushenko was invited as a "special guest" to conduct the draw. For each announced club from the ranking list a ball with a number was drawn from a pot. According to the number, the announced club was placed into the seed with the corresponding number. The first club that was announced was FC Shakhtar Donetsk.

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