The 2010–11 NCAA Division I men's basketball season began on November 8, 2010 with the preliminary games of the 2010 Coaches Vs. Cancer Classic, and ended with the 2011 NCAA Men's Division I Basketball Tournament's championship game on April 4, 2011 at Reliant Stadium in Houston. The tournament's first round games occurred March 15–16, 2011 in Dayton, followed by second and third rounds on Thursday through Sunday, March 17–20, 2011. Regionals games will be played on Thursday through Sunday, March 24–27, 2011, with the Final Four played on Saturday and Monday, April 2 and 4, 2011.

The top 25 from the AP and ESPN/USA Today Coaches Polls, October 28, 2010.

A number of early-season tournaments marked the beginning of the college basketball season.

*Although these tournaments include more teams, only 4 play for the championship.

Thirty athletic conferences each end their regular seasons with a single-elimination tournament. The teams in each conference that win their regular season title are given the number one seed in each tournament. The winners of these tournaments receive automatic invitations to the 2011 NCAA Men's Division I Basketball Tournament. The Ivy League does not have a conference tournament, instead giving their automatic invitation to their regular-season champion. By contrast, the Atlantic Coast Conference does not have a regular-season champion, using the standings only for seeding purposes in its conference tournament.

A "major upset" is defined as a win by a team seeded 7 or more spots below its defeated opponent.

After the NCAA Tournament field was announced, the National Invitation Tournament invited 32 teams to participate.

Played at Madison Square Garden in New York City

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