The 2007–08 season was the 116th season in Liverpool Football Club's existence, and their 45th consecutive year in the top flight, which covers the period from 1 July 2007 to 30 June 2008.

Having finished third the previous season, Liverpool had qualified for the UEFA Champions League final qualifying stage.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Liverpool began their Premier League season with a trip to Aston Villa, which they won 2–1. This was followed by the first leg of the Champions League qualifier, at Toulouse. The game, unusually played on a weekday afternoon, was won 1–0 by Liverpool. Next came the first home game, a Premier League game against Chelsea. Liverpool took a lead through Fernando Torres's first goal for the club, but Chelsea hit back with a disputed penalty, ending the game 1–1. Referee Rob Styles appeared to book Michael Essien twice without sending him off, similar to Graham Poll at the 2006 World Cup. Styles later admitted to have made an incorrect decision to award the penalty and, unusually, apologised to Liverpool for his mistake; he was subsequently dropped for the next gameweek.

The third league game of the season, a 2–0 away win at Sunderland, was notable for Mohamed Sissoko's first (and only) Liverpool goal, after more than two years. This was also the Reds' 7,000th league goal. The following Tuesday saw Liverpool play Toulouse at Anfield in the second leg of their Champions League qualifying tie. Before kick-off, the Everton song "Z Cars" echoed around Anfield, in memory of 11-year-old Rhys Jones, a local boy who had been shot dead the previous week. The game finished 4–0 to Liverpool, and the team thereby qualified for the group stage courtesy of a 5–0 aggregate scoreline.

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