2006 Western & Southern Financial Group Masters – Singles
| Singles | |
|---|---|
| 2006 Western & Southern Financial Group Masters | |
| Champion |
 Andy Roddick
|
| Runner-up |
 Juan Carlos Ferrero
|
| Final score | 6–3, 6–4 |
Roger Federer was the defending champion but lost in the second round to unseeded Andy Murray, in what would be Federer's only defeat prior to the final that year.
Andy Roddick won in the final against Juan Carlos Ferrero 6–3, 6–4.
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