2006 NASDAQ-100 Open – Women's Singles
| Women's Singles | |
|---|---|
| 2006 NASDAQ-100 Open | |
| Champion |
 Svetlana Kuznetsova
|
| Runner-up |
Maria Sharapova
|
| Final score | 6–4, 6–3 |
Kim Clijsters was the defending champion, but lost in the second round to Jill Craybas.
Svetlana Kuznetsova won in an all-Russian final, 6–4, 6–3, against Maria Sharapova. It was her first Tier I title and sixth overall, and her first title of any kind since September 2004.
All seeds received a bye into the second round.
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