The 2006 Grand Prix de Tennis de Lyon was a men's tennis tournament played on indoor hard courts. It was played at the Palais des Sports de Gerland in Lyon in France and was part of the International Series tournaments of the 2006 ATP Tour. The tournament took place from October 23 through October 30, 2006. Richard Gasquet won the singles title.

Richard Gasquet defeated Marc Gicquel 6–3, 6–1

Julien Benneteau / Arnaud Clément defeated František Čermák / Jaroslav Levinský 6–2, 6–7^(3–7), [10–7]