2005 U.S. Open – Men's Singles
| Men's Singles | |
|---|---|
| 2005 US Open | |
| Champion |
 Roger Federer
|
| Runner-up |
 Andre Agassi
|
| Final score | 6–3, 2–6, 7–6(7–1), 6–1 |
Roger Federer defeated Andre Agassi 6–3, 2–6, 7–6(7–1), 6–1 in the final to win the Men's Singles tennis title at the 2005 US Open. This was Agassi's last appearance in a Grand Slam tournament final.
This was the first US Open that future champions Novak Djokovic, Andy Murray and Stan Wawrinka competed in the main draw.
Noteworthy in this tournament was a strong performance by the American men, despite former champion and world #1 Andy Roddick losing in the first round.
Wildcard James Blake made the quarterfinal, upsetting #2 Rafael Nadal in the third round before eventually losing to Agassi in a five-set match.
Unheralded American Robby Ginepri, whose run was enhanced by Roddick's early defeat, made it all the way to the semi-final and lost to Agassi in another five- setter.
The seeded players are listed below. Roger Federer is the champion; others show the round in which they were eliminated.
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