The 2005 Major League Baseball All-Star Game was the 76th playing of the midseason exhibition baseball game between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 12, 2005 at Comerica Park in Detroit, Michigan, the home of the Detroit Tigers of the American League. The game resulted in the American League defeating the National League 7–5, thus awarding an AL team (which eventually came to be the Chicago White Sox) home-field advantage in the 2005 World Series. The game was when Rawlings first previewed the Coolflo batting helmets.

Players in italics have since been inducted into the National Baseball Hall of Fame.

Notes

National League: Tony LaRussa
American League: Terry Francona

Before the game, a superchoir consisting of three choirs from Windsor, Ontario, sang "O Canada", the Canadian National Anthem. Then, a moment of silence for the victims of the July 7 London bombings, which took place a few days before the game, followed by the Detroit Symphony Orchestra Brass Players' performance of "God Save the Queen", the national anthem of the United Kingdom. Brian McKnight sang The Star-Spangled Banner, the U.S. National Anthem. The colors presentation was by the Camp Grayling color guard, accompanied by University of Toledo ROTC officers who presented the flags in the outfield.

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