The 2005–06 Detroit Pistons season was the 65th season of the franchise, the 58th in the National Basketball Association (NBA), and the 49th in the Detroit area. They Pistons began the season hoping to improve upon their 54–28 output from the previous season and have another chance of going to the NBA Finals after losing to the San Antonio Spurs in last season's NBA Finals in seven games. They bested it by ten games, finishing 64–18—their best record in franchise history—and qualifying for the playoffs for the fifth straight season. The Pistons reached the Eastern Conference Finals for the fourth consecutive year before losing to the eventual NBA champions Miami Heat, whom they had beaten in a seven-game playoff series the year before. Detroit's offseason was soon marked by the departure of star defensive player Ben Wallace, who signed a free-agent deal with the Chicago Bulls.

For the season, the Pistons had a new logo and though they kept the uniforms, the horse logo was replaced by the letter 'P' on the left side of the shorts.

(1) Detroit Pistons vs. (8) Milwaukee Bucks

Last Playoffs meeting: 2004 Eastern Conference First Round (Detroit won 4–1)

(1) Detroit Pistons vs. (4) Cleveland Cavaliers

Last Playoffs meeting: This is the first meeting between the Pistons and Cavaliers.

(1) Detroit Pistons vs. (2) Miami Heat

Last Playoffs meeting: 2005 Eastern Conference Finals (Detroit won 4–3)

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