2004 NASDAQ-100 Open – Women's Singles
| Women's Singles | |
|---|---|
| 2004 NASDAQ-100 Open | |
| Champion |
 Serena Williams
|
| Runner-up |
 Elena Dementieva
|
| Final score | 6–1, 6–1 |
Serena Williams was the two-time defending champion and successfully defended her title by defeating Elena Dementieva 6–1, 6–1 in the final.
This tournament featured the first ever career meeting between Williams and Maria Sharapova. Williams won in straight sets in the fourth round.
All seeded players receive a bye into the second round.
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