The 1999-2000 Los Angeles Clippers season was their 30th season in the NBA, their 16th in Los Angeles. During the offseason, the Clippers acquired Derek Anderson from the Cleveland Cavaliers, and began playing in their new arena, the Staples Center. The Clippers are co-tenants with their crosstown rival, the Los Angeles Lakers. Late in the season, the team signed free agent Jeff McInnis as Troy Hudson was released. While the Lakers were on their way to an NBA title, the Clippers sank to the bottom of the Pacific Division with a league worst record of 15–67, as the team posted long losing streaks throughout the season. Top draft pick Lamar Odom provided a bright spot as he averaged a solid 16.6 points per game, and made the All-Rookie First Team. Following the season, Anderson signed as a free agent with the San Antonio Spurs, and Maurice Taylor signed with the Houston Rockets.

The Clippers have been involved in the following transactions during the 1999-2000 season.

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