The 1978 Family Circle Cup was a women's tennis tournament played on outdoor clay courts at the Sea Pines Plantation on Hilton Head Island, South Carolina in the United States. The event was part of the AAA category of the 1978 Colgate Series. It was the sixth edition of the tournament and was held from April 10 through April 16, 1978. First-seeded Chris Evert won the singles title and earned $25,000 first-prize money.

Chris Evert defeated Kerry Reid 6–2, 6–0