The 1972 Sandown 250 was an endurance motor race for Group E Series Production Touring Cars. It was held on 10 September 1972 over 130 laps of the Sandown circuit in Victoria, Australia, a total distance of 250 miles (403 km). The race was Heat 2 of the 1972 Australian Manufacturers' Championship.
As a heat of the 1972 Australian Manufacturers' Championship, the race featured four classes defined by "Capacity Price Units". The CP Unit value for each car was assessed by multiplying the engine capacity (in litres) by the Sydney retail price (in Australian dollars).
Note: Of the 43 starters, 22 were classified as finishers and 2 completed insufficient laps to be classified.