The 1972 Major League Baseball All-Star Game, the 43rd such game, was played on July 25, 1972. The all-stars from the American League and the National League faced each other at Atlanta Stadium, home of the Atlanta Braves. The National League came away with a 4–3 win in 10 innings.

This was the third All-Star Game hosted by the Braves (1936 and 1955), but the first All-Star Game to be hosted by the team in Atlanta (the previous two being hosted in their previous homes of Boston and Milwaukee, respectively). This would be the only All-Star Game played in Atlanta Stadium, as the Braves had moved to Turner Field when the exhibition returned to Atlanta in 2000.

After seeing their 8 All-Star Game winning streak ended in 1971, the game would mark the start of an 11-game winning streak for the NL, the longest winning streak by either league in the exhibition's history. This was also the final All-Star Game for Roberto Clemente before his death in a plane crash on New Year's Eve.

The American League roster included 13 future Hall of Fame players and coaches.

The National League roster included 16 future Hall of Fame players and coaches.

While the starters were elected by the fans, the batting orders and starting pitchers were selected by the managers.

The American League opened the game's scoring in the top of the third, with Steve Blass in to relieve Bob Gibson. Bill Freehan walked, and advanced to second base on a sacrifice bunt by Jim Palmer. Rod Carew singled, allowing Freehan to score.

The National League would not answer until the bottom of the sixth inning, with Gaylord Perry pitching in relief. With two outs, César Cedeño singled. Hank Aaron then hit a two run home run to give the National League the lead.

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