The 1953 Major League Baseball All-Star Game was the 20th playing of the mid-summer classic between the All-Stars teams of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 14, 1953, at Crosley Field in Cincinnati, home of the Cincinnati Redlegs National League team. The team changed its name from Reds to Redlegs during the height of anti-communism in the United States.

From 1949 through 1952, manager Casey Stengel had taken the New York Yankees to four consecutive World Series titles, but this time turned on his fourth defeat in a row at the helm of the American League team.

Robin Roberts (NL) and Billy Pierce (AL) found themselves in a pitching duel during three innings of one-hit shutout ball, but they were not a factor in the decision. AL relievers Allie Reynolds (2), Mike Garcia (1) and Satchel Paige (2) combined to give up five runs to the NL hitters.

The NL attack was led by Enos Slaughter, who went 2-for-3 with two runs and an RBI, while Pee Wee Reese hit a single and a double and drove in two runs. Minnie Miñoso went 2-for-2 and drove in the only run for the AL team.

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