17β-hydroxysteroid dehydrogenase III

HSD17B3
Identifiers
Aliases	HSD17B3, EDH17B3, SDR12C2, hydroxysteroid (17-beta) dehydrogenase 3, hydroxysteroid 17-beta dehydrogenase 3
External IDs	MGI: 107177 HomoloGene: 20089 GeneCards: HSD17B3
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.32 Start 96,235,306 bp End 96,302,152 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 B3 Start 64,058,266 bp End 64,089,230 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • testosterone 17-beta-dehydrogenase (NADP+) activity • oxidoreductase activity • testosterone dehydrogenase (NAD+) activity Cellular component • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • testosterone biosynthetic process • steroid biosynthetic process • lipid metabolic process • androgen biosynthetic process • oxidation-reduction process • male genitalia development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3293	15487
Ensembl	ENSG00000130948	ENSMUSG00000033122
UniProt	P37058 Q6FH62	P70385
RefSeq (mRNA)	NM_000197	NM_008291
RefSeq (protein)	NP_000188 NP_000188.1	NP_032317
Location (UCSC)	Chr 9: 96.24 – 96.3 Mb	Chr 9: 64.06 – 64.09 Mb
PubMed search

3293

15487

ENSG00000130948

ENSMUSG00000033122

P37058
Q6FH62

P70385

NM_000197

NM_008291

NP_000188
NP_000188.1

NP_032317

17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in androgen steroidogenesis.

This isoform of 17β-HSD is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.

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