140–142 Hospital Street, sometimes known as Hospital House, is a substantial townhouse in Nantwich, Cheshire, England, located on the south side of Hospital Street (at SJ6557452166). The building is listed at grade II. It was built in the late 16th century by John Crewe, a tanner, whose sons Randolph and Thomas both served as the Speaker of the House of Commons. The original timber-framed, close-studded façade has been concealed by alterations during the late 17th century; these include the addition of small-paned casement windows, some of which contain old heraldic stained glass. The building was further altered and extended in the 18th century, with the addition of two Gothic-style entrances. Later occupants include the architect, Thomas Bower, and the building remains in residential use.
The present building is believed to stand on the site of the medieval Hospital of St Nicholas, which gives Hospital Street its name. Stone remains discovered in the garden have been associated with the hospital.
Historian James Hall tentatively identifies the existing building as standing on the site of the medieval Hospital of St Nicholas, which was established at the end of Hospital Street and gives the street its name. Founded by William Malbank, the first baron of Nantwich, in 1083–84, the hospice was a religious house which accommodated sick or infirm travellers and gave alms to the poor. It was dissolved in 1548; on 11 November of the following year, Edward VI granted "a House and manse formerly called the Chapel of St. Nicholas", together with associated land and property, to Sir Thomas Bromley of Nantwich, a justice of the King's Bench. By 1569, Bromley had sold it to Richard Wright. The original site of the Wright's Almshouses, built in 1638, was on part of the former hospice's land.