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1,2-dichloropropane

1,2-Dichloropropane
1,2-dichloropropane skeletal.png
Names
IUPAC name
1,2-Dichloropropane
Other names
Propylene dichloride
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.001.048
KEGG
PubChem CID
UNII
Properties
C3H6Cl2
Molar mass 112.98 g·mol−1
Appearance Colorless liquid
Odor like chloroform
Density 1.156 g/cm3
Melting point −100 °C (−148 °F; 173 K)
Boiling point 95 to 96 °C (203 to 205 °F; 368 to 369 K)
0.26 g/100 mL (at 20 °C)
Vapor pressure 40 mmHg (20°C)
Hazards
R-phrases (outdated) R11 R20/22
S-phrases (outdated) S16 S24
Flash point 16 °C (61 °F; 289 K)
557 °C (1,035 °F; 830 K)
Explosive limits 3.4%-14.5%
Lethal dose or concentration (LD, LC):
LD50 (median dose)
860 mg/kg (mouse, oral)
1947 mg/kg (rat, oral)
2000 mg/kg (guinea pig, oral)
2000 ppm (rat, 4 hr)
720 ppm (mouse, 10 hr)
2980 ppm (rat, 8 hr)
US health exposure limits (NIOSH):
PEL (Permissible)
TWA 75 ppm (350 mg/m3)
REL (Recommended)
Ca
IDLH (Immediate danger)
Ca [400 ppm]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YesYN ?)
Infobox references

1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.

1,2-Dichloropropane is an intermediate in the production of perchloroethylene and other chlorinated chemicals. It was once used as a soil fumigant, chemical intermediate, as well as an industrial solvent and was found in paint strippers, varnishes, and furniture finish removers but some of these uses have been discontinued.

Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.

Data from animal studies show tumor growth in the liver and mammary glands. Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.


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