Β-fibrinogen

FGB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FZA, 1FZB, 1FZC, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3BVH, 3E1I, 3GHG, 3H32, 3HUS
Identifiers
Aliases	FGB, HEL-S-78p, fibrinogen beta chain
External IDs	MGI: 99501 HomoloGene: 3772 GeneCards: FGB
Gene location (Human) Chr. Chromosome 4 (human) Band 4q31.3 Start 154,562,956 bp End 154,571,086 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 E3|3 36.98 cM Start 83,040,141 bp End 83,049,863 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • chaperone binding • structural molecule activity • protein binding • receptor binding • cell adhesion molecule binding Cellular component • cytoplasm • platelet alpha granule • extracellular vesicle • blood microparticle • plasma membrane • fibrinogen complex • extracellular region • cell surface • cell cortex • extracellular exosome • platelet alpha granule lumen • external side of plasma membrane • extracellular space Biological process • hemostasis • negative regulation of endothelial cell apoptotic process • positive regulation of peptide hormone secretion • protein polymerization • positive regulation of heterotypic cell-cell adhesion • adaptive immune response • fibrinolysis • immune system process • platelet degranulation • blood coagulation • cellular protein complex assembly • extracellular matrix organization • cellular response to leptin stimulus • response to calcium ion • positive regulation of substrate adhesion-dependent cell spreading • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of vasoconstriction • cellular response to interleukin-1 • positive regulation of protein secretion • positive regulation of ERK1 and ERK2 cascade • positive regulation of exocytosis • blood coagulation, fibrin clot formation • plasminogen activation • innate immune response • cell-matrix adhesion • platelet aggregation • signal transduction • induction of bacterial agglutination • platelet activation • toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2244	110135
Ensembl	ENSG00000171564	ENSMUSG00000033831
UniProt	P02675	Q8K0E8
RefSeq (mRNA)	NM_001184741 NM_005141	NM_181849
RefSeq (protein)	NP_001171670 NP_005132	NP_862897
Location (UCSC)	Chr 4: 154.56 – 154.57 Mb	Chr 4: 83.04 – 83.05 Mb
PubMed search

1FZA, 1FZB, 1FZC, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3BVH, 3E1I, 3GHG, 3H32, 3HUS

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