Β-catenin

CTNNB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G3J, 1JDH, 1JPW, 1LUJ, 1P22, 1QZ7, 1T08, 1TH1, 2GL7, 2Z6H, 3DIW, 3SL9, 3SLA, 3TX7, 4DJS, 3FQN, 3FQR
Identifiers
Aliases	CTNNB1, CTNNB, MRD19, armadillo, catenin beta 1, EVR7
External IDs	OMIM: 116806 MGI: 88276 HomoloGene: 1434 GeneCards: CTNNB1
Gene ontology Molecular function • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • DNA binding • protein binding • SMAD binding • chromatin binding • signal transducer activity • double-stranded DNA binding • repressing transcription factor binding • protein C-terminus binding • protein kinase binding • kinase binding • androgen receptor binding • ion channel binding • estrogen receptor binding • I-SMAD binding • transcription regulatory region DNA binding • protein phosphatase binding • transcription factor binding • transcription coactivator activity • nuclear hormone receptor binding • alpha-catenin binding • enzyme binding • RNA polymerase II core promoter sequence-specific DNA binding • protein heterodimerization activity • cadherin binding Cellular component • adherens junction • beta-catenin destruction complex • protein-DNA complex • lamellipodium • beta-catenin-TCF complex • beta-catenin-TCF7L2 complex • centrosome • Z disc • bicellular tight junction • transcription factor complex • lateral plasma membrane • cytoplasm • cell cortex • apical part of cell • spindle pole • Scrib-APC-beta-catenin complex • catenin-TCF7L2 complex • nuclear euchromatin • flotillin complex • intercalated disc • nucleus • cell-cell junction • membrane • Wnt signalosome • cell-cell adherens junction • basolateral plasma membrane • plasma membrane • nuclear transcription factor complex • cytoskeleton • extracellular exosome • nucleoplasm • microtubule organizing center • cell periphery • apical junction complex • cell projection membrane • focal adhesion • microvillus membrane • fascia adherens • cytosol • cell junction • protein complex • perinuclear region of cytoplasm • catenin complex • synapse Biological process • embryonic brain development • negative regulation of cell proliferation • renal vesicle formation • positive regulation of MAPK cascade • proximal/distal pattern formation • positive regulation of neuroblast proliferation • chemical synaptic transmission • central nervous system vasculogenesis • renal inner medulla development • transcription, DNA-templated • positive regulation of neuron apoptotic process • canonical Wnt signaling pathway • embryonic foregut morphogenesis • endoderm formation • endodermal cell fate commitment • synapse organization • trachea formation • cellular process • positive regulation of telomere maintenance via telomerase • neural plate development • negative regulation of protein sumoylation • lung cell differentiation • vasculogenesis • cellular protein localization • lung induction • hemopoiesis • kidney development • positive regulation of gene expression • adherens junction organization • renal outer medulla development • thymus development • regulation of myelination • positive regulation of cell proliferation • epithelial tube branching involved in lung morphogenesis • bone resorption • epithelial cell differentiation involved in prostate gland development • regulation of euchromatin binding • hair follicle morphogenesis • hair follicle placode formation • neuron migration • negative regulation of chondrocyte differentiation • fungiform papilla formation • positive regulation of type I interferon production • negative regulation of mitotic cell cycle, embryonic • ectoderm development • trachea morphogenesis • T cell differentiation in thymus • pancreas development • cranial ganglion development • regulation of apoptotic process • lung development • positive regulation of skeletal muscle tissue development • synaptic vesicle transport • positive regulation of telomerase activity • morphogenesis of embryonic epithelium • renal system development • oocyte development • hair cycle process • embryonic axis specification • chromatin-mediated maintenance of transcription • embryonic forelimb morphogenesis • anterior/posterior axis specification • positive regulation of endothelial cell differentiation • regulation of transcription from RNA polymerase II promoter • animal organ development • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • dorsal/ventral axis specification • positive regulation of muscle cell differentiation • positive regulation of apoptotic process • regulation of protein localization to cell surface • androgen receptor signaling pathway • nervous system development • forebrain development • hair cell differentiation • negative regulation of transcription from RNA polymerase II promoter • regulation of epithelial cell differentiation • positive regulation of histone H3-K4 methylation • embryonic digit morphogenesis • endothelial tube morphogenesis • osteoclast differentiation • regulation of transcription, DNA-templated • regulation of osteoclast differentiation • response to drug • neuron differentiation • epithelial to mesenchymal transition • cell fate specification • odontogenesis of dentin-containing tooth • midbrain development • positive regulation of mesenchymal cell proliferation • positive regulation of heparan sulfate proteoglycan biosynthetic process • smooth muscle cell differentiation • glial cell fate determination • cell fate determination • positive regulation of determination of dorsal identity • regulation of T cell proliferation • gastrulation with mouth forming second • negative regulation of apoptotic signaling pathway • oviduct development • cellular response to growth factor stimulus • male genitalia development • negative regulation of gene expression • nephron tubule formation • regulation of osteoblast differentiation • regulation of angiogenesis • cell morphogenesis involved in differentiation • cell-matrix adhesion • dorsal root ganglion development • regulation of cell proliferation • embryonic skeletal limb joint morphogenesis • heart development • T cell differentiation • dorsal/ventral pattern formation • layer formation in cerebral cortex • canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation • canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition • positive regulation of osteoblast differentiation • negative regulation of osteoclast differentiation • regulation of core promoter binding • genitalia morphogenesis • negative regulation of neuron death • cell maturation • cell proliferation • branching involved in ureteric bud morphogenesis • cell differentiation • protein localization to cell surface • embryonic hindlimb morphogenesis • negative regulation of oligodendrocyte differentiation • metanephros morphogenesis • regulation of centriole-centriole cohesion • limb development • positive regulation of epithelial cell proliferation involved in prostate gland development • regulation of secondary heart field cardioblast proliferation • regulation of fibroblast proliferation • regulation of smooth muscle cell proliferation • skin development • skeletal system development • hindbrain development • regulation of calcium ion import • mesenchymal cell proliferation involved in lung development • regulation of nephron tubule epithelial cell differentiation • cellular response to indole-3-methanol • canonical Wnt signaling pathway involved in negative regulation of apoptotic process • regulation of gene expression • regulation of cell differentiation • stem cell population maintenance • regulation of neurogenesis • positive regulation of chromatin-mediated maintenance of transcription • in utero embryonic development • lung-associated mesenchyme development • negative regulation of cell differentiation • positive regulation of I-kappaB kinase/NF-kappaB signaling • vasculature development • sympathetic ganglion development • positive regulation of epithelial cell differentiation • positive regulation of branching involved in lung morphogenesis • lens morphogenesis in camera-type eye • positive regulation of epithelial to mesenchymal transition • positive regulation of fibroblast growth factor receptor signaling pathway • embryonic heart tube development • regulation of centromeric sister chromatid cohesion • positive regulation of DNA-templated transcription, initiation • positive regulation of transcription, DNA-templated • branching involved in blood vessel morphogenesis • single organismal cell-cell adhesion • positive regulation of sequence-specific DNA binding transcription factor activity • cell adhesion • negative regulation of transcription, DNA-templated • adherens junction assembly • positive regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway, calcium modulating pathway • beta-catenin-TCF complex assembly • catenin import into nucleus • beta-catenin destruction complex disassembly • cranial skeletal system development • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • response to estradiol • midbrain dopaminergic neuron differentiation • entry of bacterium into host cell • negative regulation of oxidative stress-induced neuron death • positive regulation of core promoter binding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1499	12387
Ensembl	ENSG00000168036	ENSMUSG00000006932
UniProt	P35222	Q02248
RefSeq (mRNA)	NM_001098209 NM_001098210 NM_001904 NM_001330729	NM_001165902 NM_007614
RefSeq (protein)	NP_001091679 NP_001091680 NP_001317658 NP_001895	NP_001159374 NP_031640
Location (UCSC)	Chr 3: 41.19 – 41.26 Mb	Chr 9: 120.93 – 120.96 Mb
PubMed search

1G3J, 1JDH, 1JPW, 1LUJ, 1P22, 1QZ7, 1T08, 1TH1, 2GL7, 2Z6H, 3DIW, 3SL9, 3SLA, 3TX7, 4DJS, 3FQN, 3FQR

1499

12387

ENSG00000168036

ENSMUSG00000006932

P35222

Q02248

NM_001098209
NM_001098210
NM_001904
NM_001330729

...
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