Α2C-adrenergic

ADRA2C
Identifiers
Aliases	ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, adrenoceptor alpha 2C
External IDs	MGI: 87936 HomoloGene: 20170 GeneCards: ADRA2C
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 3,766,348 bp End 3,768,526 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band n/a Start 35,278,319 bp End 35,281,763 bp
Gene ontology Molecular function • G-protein coupled receptor activity • epinephrine binding • protein homodimerization activity • signal transducer activity • adrenergic receptor activity • protein binding • alpha-2A adrenergic receptor binding • alpha2-adrenergic receptor activity • protein heterodimerization activity Cellular component • cytoplasm • axon terminus • integral component of membrane • endosome • membrane • plasma • integral component of plasma membrane • axon Biological process • G-protein coupled receptor signaling pathway • activation of protein kinase B activity • negative regulation of epinephrine secretion • regulation of sensory perception of pain • regulation of smooth muscle contraction • regulation of insulin secretion • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway • female pregnancy • cell-cell signaling • negative regulation of norepinephrine secretion • negative regulation of uterine smooth muscle contraction • activation of MAPK activity by adrenergic receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of vasoconstriction • positive regulation of neuron differentiation • positive regulation of vasoconstriction • signal transduction • platelet activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	152	11553
Ensembl	ENSG00000184160	ENSMUSG00000045318
UniProt	P18825	Q01337
RefSeq (mRNA)	NM_000683	NM_007418
RefSeq (protein)	NP_000674	NP_031444
Location (UCSC)	Chr 4: 3.77 – 3.77 Mb	Chr 4: 35.28 – 35.28 Mb
PubMed search

152

11553

ENSG00000184160

ENSMUSG00000045318

P18825

Q01337

NM_000683

NM_007418

NP_000674

NP_031444

The alpha-2C adrenergic receptor (α_2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.

Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha_2A, alpha_2B, and alpha_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the alpha_2A and alpha_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha_2C subtype modulated neurotransmission at lower levels of nerve activity.

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