Α2A-adrenergic

ADRA2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HLL, 1HO9, 1HOD, 1HOF
Identifiers
Aliases	ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A
External IDs	MGI: 87934 HomoloGene: 47944 GeneCards: ADRA2A
Gene location (Human) Chr. Chromosome 10 (human) Band 10q25.2 Start 111,077,163 bp End 111,080,907 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 D2|19 49.04 cM Start 54,045,182 bp End 54,048,982 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • alpha-2C adrenergic receptor binding • G-protein coupled receptor activity • protein homodimerization activity • epinephrine binding • norepinephrine binding • alpha-1B adrenergic receptor binding • signal transducer activity • adrenergic receptor activity • protein binding • alpha2-adrenergic receptor activity • protein heterodimerization activity • thioesterase binding • heterotrimeric G-protein binding • protein kinase binding Cellular component • integral component of membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane • basolateral plasma membrane • cytoplasm Biological process • G-protein coupled receptor signaling pathway • positive regulation of epidermal growth factor-activated receptor activity • negative regulation of adenylate cyclase activity • movement of cell or subcellular component • activation of protein kinase B activity • negative regulation of insulin secretion • positive regulation of MAP kinase activity • negative regulation of epinephrine secretion • glucose homeostasis • regulation of smooth muscle contraction • positive regulation of cytokine production • regulation of insulin secretion • positive regulation of cell migration • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway • positive regulation of potassium ion transport • phospholipase C-activating adrenergic receptor signaling pathway • positive regulation of wound healing • negative regulation of norepinephrine secretion • positive regulation of membrane protein ectodomain proteolysis • negative regulation of insulin secretion involved in cellular response to glucose stimulus • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • negative regulation of calcium ion transmembrane transporter activity • activation of MAPK activity by adrenergic receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • cellular response to hormone stimulus • regulation of vasoconstriction • negative regulation of calcium ion-dependent exocytosis • Rho protein signal transduction • positive regulation of cell proliferation • negative regulation of cAMP biosynthetic process • negative regulation of calcium ion transport • intestinal absorption • negative regulation of adrenergic receptor signaling pathway • Ras protein signal transduction • negative regulation of lipid catabolic process • activation of protein kinase activity • actin cytoskeleton organization • signal transduction • platelet activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	150	11551
Ensembl	ENSG00000150594	ENSMUSG00000033717
UniProt	P08913	Q01338 Q3URE6
RefSeq (mRNA)	NM_000681	NM_007417
RefSeq (protein)	NP_000672	NP_031443
Location (UCSC)	Chr 10: 111.08 – 111.08 Mb	Chr 10: 54.05 – 54.05 Mb
PubMed search

1HLL, 1HO9, 1HOD, 1HOF

150

11551

ENSG00000150594

ENSMUSG00000033717

P08913

Q01338
Q3URE6

NM_000681

NM_007417

NP_000672

NP_031443

The alpha-2A adrenergic receptor (α_2A adrenoceptor), also known as ADRA2A, is an α₂ adrenergic receptor, and also denotes the human gene encoding it.

α₂ adrenergic receptors include 3 highly homologous subtypes: α_2A, α_2B, and α_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α_2A and α_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α_2C subtype modulated neurotransmission at lower levels of nerve activity.

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Wikipedia