Ōmiya-shuku (大宮宿 Ōmiya-shuku?) was the fourth of the sixty-nine stations of the Nakasendō. It is located in the Ōmiya ward and Kita ward of the present-day city of Saitama, Saitama Prefecture, Japan.
Larger than its two neighboring post towns, Urawa-shuku and Ageo-shuku, Ōmiya-shuku was recorded to have had a population of over 1,500 people with over 300 homes during the Tenpō era. It also had the largest number (nine) of secondary honjin along the Nakasendō.