Prion protein

PRNP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2OL9, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NHD, 3NVF, 4DGI, 4E1H, 4E1I,%%s1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2M8T, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NVF, 4DGI, 4E1H, 4E1I, 4KML, 4N9O
Identifiers
Aliases	PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
External IDs	OMIM: 176640 MGI: 97769 HomoloGene: 7904 GeneCards: PRNP
Gene location (Human) Chr. Chromosome 20 (human) Band 20p13 Start 4,686,236 bp End 4,701,590 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 F2|2 64.07 cM Start 131,909,928 bp End 131,938,429 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • chaperone binding • ion channel binding • microtubule binding • ATP-dependent protein binding • metal ion binding • tubulin binding • protein binding • identical protein binding • copper ion binding • lamin binding Cellular component • mitochondrial outer membrane • membrane • mitochondrion • integral component of membrane • cytoplasm • Golgi apparatus • plasma membrane • cell surface • endoplasmic reticulum • membrane raft • anchored component of membrane • extracellular exosome • nucleus • extrinsic component of membrane Biological process • negative regulation of protein phosphorylation • negative regulation of interferon-gamma production • response to cadmium ion • negative regulation of calcineurin-NFAT signaling cascade • response to copper ion • negative regulation of apoptotic process • response to oxidative stress • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of T cell receptor signaling pathway • regulation of protein localization • negative regulation of activated T cell proliferation • cellular response to drug • cell cycle arrest • learning or memory • cellular copper ion homeostasis • cellular response to copper ion • cell cycle • metabolism • negative regulation of interleukin-17 production • protein homooligomerization • negative regulation of interleukin-2 production • regulation of potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5621	19122
Ensembl	ENSG00000171867	ENSMUSG00000079037
UniProt	P04156	P04925
RefSeq (mRNA)	NM_183079 NM_000311 NM_001080121 NM_001080122 NM_001080123 NM_001271561	NM_001278256 NM_011170
RefSeq (protein)	NP_000302 NP_001073590 NP_001073591 NP_001073592 NP_001258490 NP_898902 NP_000302.1 NP_001073590.1 NP_001073591.1 NP_001073592.1 NP_898902.1	NP_001265185 NP_035300
Location (UCSC)	Chr 20: 4.69 – 4.7 Mb	Chr 20: 131.91 – 131.94 Mb
PubMed search

1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2OL9, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NHD, 3NVF, 4DGI, 4E1H, 4E1I,%%s1E1G, 1E1J, 1E1P, 1E1S, 1E1U, 1E1W, 1FKC, 1FO7, 1H0L, 1HJM, 1HJN, 1I4M, 1OEH, 1OEI, 1QLX, 1QLZ, 1QM0, 1QM1, 1QM2, 1QM3, 2IV4, 2IV5, 2IV6, 2K1D, 2KUN, 2LBG, 2LEJ, 2LFT, 2LSB, 2LV1, 2M8T, 2W9E, 3HAF, 3HAK, 3HEQ, 3HER, 3HES, 3HJ5, 3HJX, 3MD4, 3MD5, 3NHC, 3NVF, 4DGI, 4E1H, 4E1I, 4KML, 4N9O

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