Prasterone enanthate

Prasterone enanthate

Clinical data
Trade names	Gynodian Depot (with estradiol valerate)
Synonyms	DHEA enanthate; Prasterone heptanoate; DHEA heptanoate; DHEA-E; EDHEA; Androst-5-en-3β-ol-17-one 3β-heptanoate
Routes of administration	Intramuscular injection
Drug class	Androgen; Anabolic steroid; Androgen ester; Estrogen; Neurosteroid
ATC code	G03EA03 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Duration of action	18 days
Identifiers
IUPAC name [(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] heptanoate
CAS Number	23983-43-9
PubChem CID	163331
ChemSpider	143333
UNII	2W8I1S6T5L
Chemical and physical data
Formula	C26H40O3
Molar mass	400.60 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CCC4=O)C)C
InChI InChI=1S/C26H40O3/c1-4-5-6-7-8-24(28)29-19-13-15-25(2)18(17-19)9-10-20-21-11-12-23(27)26(21,3)16-14-22(20)25/h9,19-22H,4-8,10-17H2,1-3H3/t19-,20-,21-,22-,25-,26-/m0/s1 Key:HHENOUDBWKNPAB-BNCSLUSBSA-N

Prasterone enanthate (also known as prasterone heptanoate, dehydroepiandrosterone enanthate, DHEA enanthate, DHEA-E, or androst-5-en-3β-ol-17-one 3β-heptanoate) is a synthetic, injected, long-lasting ester prodrug of dehydroepiandrosterone (DHEA), a weak androgen and neurosteroid. It is a component of Gynodian Depot, a combination formulation of 4 mg estradiol valerate and 200 mg prasterone enanthate in oil for depot intramuscular injection that is used in the treatment of menopausal symptoms and is marketed in Europe and South America. Prasterone enanthate has an average duration of 18 days in this formulation. The drug was patented, by Schering, in 1971.