Lactoferrin

LTF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PMS, 1B0L, 1BKA, 1CB6, 1DSN, 1EH3, 1FCK, 1H43, 1H44, 1H45, 1HSE, 1L5T, 1LCF, 1LCT, 1LFG, 1LFH, 1LFI, 1LGB, 1N76, 1SQY, 1U62, 1VFD, 1VFE, 1XV4, 1XV7, 1Z6V, 1Z6W, 2BJJ, 2DP4, 2GMC, 2GMD, 2HD4
Identifiers
Aliases	LTF, GIG12, HEL110, HLF2, LF, lactotransferrin
External IDs	OMIM: 150210 MGI: 96837 HomoloGene: 1754 GeneCards: LTF
Gene ontology Molecular function • iron ion binding • DNA binding • heparin binding • protein serine/threonine kinase activator activity • metal ion binding • peptidase activity • protein binding • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cellular component • cytoplasm • secretory granule • protein complex • extracellular region • cell surface • specific granule • phagocytic vesicle lumen • extracellular exosome • nucleus • extracellular space • specific granule lumen • tertiary granule lumen Biological process • cellular protein metabolic process • positive regulation of osteoblast proliferation • regulation of transcription, DNA-templated • positive regulation of chondrocyte proliferation • negative regulation of osteoclast development • ossification • regulation of tumor necrosis factor production • negative regulation of viral process • immune system process • negative regulation of ATPase activity • antibacterial humoral response • bone morphogenesis • iron ion homeostasis • positive regulation of bone mineralization involved in bone maturation • negative regulation of apoptotic process • ion transport • transcription, DNA-templated • proteolysis • positive regulation of protein serine/threonine kinase activity • negative regulation of single-species biofilm formation in or on host organism • negative regulation by host of viral process • negative regulation of lipopolysaccharide-mediated signaling pathway • regulation of cytokine production • negative regulation of tumor necrosis factor (ligand) superfamily member 11 production • retina homeostasis • negative regulation of viral genome replication • innate immune response in mucosa • positive regulation of osteoblast differentiation • humoral immune response • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • transport • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of toll-like receptor 4 signaling pathway • antifungal humoral response • iron assimilation by chelation and transport • antimicrobial humoral response • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4057	17002
Ensembl	ENSG00000012223	ENSMUSG00000032496
UniProt	P02788	P08071
RefSeq (mRNA)	NM_002343 NM_001199149 NM_001321121 NM_001321122	NM_008522
RefSeq (protein)	NP_001186078 NP_001308050 NP_001308051 NP_002334	NP_032548.2 NP_032548
Location (UCSC)	Chr 3: 46.44 – 46.49 Mb	Chr 9: 111.02 – 111.04 Mb
PubMed search

2PMS, 1B0L, 1BKA, 1CB6, 1DSN, 1EH3, 1FCK, 1H43, 1H44, 1H45, 1HSE, 1L5T, 1LCF, 1LCT, 1LFG, 1LFH, 1LFI, 1LGB, 1N76, 1SQY, 1U62, 1VFD, 1VFE, 1XV4, 1XV7, 1Z6V, 1Z6W, 2BJJ, 2DP4, 2GMC, 2GMD, 2HD4

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