"You and Me" is a song by American alternative rock band Lifehouse. It is the first single released from their eponymous third studio album, Lifehouse (2005). The track was written by lead singer Jason Wade and American record producer Jude Cole. It was recorded and produced by John Alagía at his home studio in Easton, Maryland. The song was first released via digital download on January 28, 2005. It was then solicited to mainstream radio on March 15, 2005. An extended wedding version of the song was then released on July 26, 2005. Musically, "You and Me" is a melodic song which, by today's standards, has a notably high emphasis on acoustics. It also contains influences of adult alternative.

The song received positive reviews from critics, who noted that the song was more mellow and stripped-down than their previous singles. It became a commercial success, charting in the top five in the United States and also charting in Australia and New Zealand. On May 19, 2005, the song was certified Gold by the RIAA for selling more than 500,000 units in the United States. In 2005, it became the ninth most downloaded song, according to Nielsen SoundScan. Because of its success, it appeared as the number one song on Billboard's list of Top 40 Adult Pop Songs from 1996–2011 on March 16, 2011. A music video for the song premiered on MTV.com on March 21, 2005, and features a couple as Wade sings in a train station. "You and Me" has appeared on many television shows, including Smallville, Grey's Anatomy, The Vampire Diaries, Cold Case and Gavin & Stacey.

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