"You Know I'm No Good" is a song by English singer and songwriter Amy Winehouse from her second and final studio album Back to Black (2006). "You Know I'm No Good" was released as the second single from Back to Black on 5 January 2007. Originally recorded as a solo track, it was remixed with guest vocals from the Wu-Tang Clan member Ghostface Killah. The original appeared on Winehouse's album, while the version with Ghostface Killah appears on his album More Fish.

Arctic Monkeys performed this song on Jo Whiley's Live Lounge on BBC Radio 1 in their second appearance there, along with their single at the time, "Brianstorm". In summer 2007, "You Know I'm No Good" was used in advertisements and in the first season opening for AMC's TV drama Mad Men, although it was replaced with the current theme song for DVD release. It was also used for the opening to ITV's Secret Diary of a Call Girl. On the recap of The Best Songs of 2007 by Entertainment Weekly magazine, this song ranked at number two.

The music video, directed by Phil Griffin (who also directed the video for her previous hit "Rehab"), was released to music channels in late November 2006. The video features Winehouse in numerous settings including a bar, a bedroom, and a bathtub. The plot is based around Winehouse's fictional character's relationship with the male character in the video. Video was shot by director of photography Adam Frisch.

The video premiered on VH1 during the weekend of 3 March 2007. Following its VH1 premiere, it was placed on MTV's Big 10 rotation as of 5 March 2007 and was premiered on TRL the same day. The song was heard on a sneak preview of AMC's original series Mad Men.

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