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Yorkshire Air Ambulance is a dedicated helicopter emergency service for the Yorkshire and the Humber region of England. It was introduced on 1 April 2000, and currently operates two Airbus H145 aircraft. The Yorkshire Air Ambulance is maintained by the Yorkshire Air Ambulance Trust, a registered charity. The air ambulance's flagship base is located at Nostell Priory and has landing pads at various major hospitals around the region including Leeds General Infirmary, Hull Royal Infirmary and James Cook University Hospital in Middlesbrough. In October 2007, a second base was opened at Sheffield City Airport. The airport then closed at the end of April 2008 but a heliport facility was still provided for the use of the air ambulance and the South Yorkshire Police helicopter. In November 2010, the operational base for the Sheffield-based aircraft was moved to Bagby Airport near Thirsk. The second aircraft then made another move in March 2012 to RAF Topcliffe, which it shares with the 645 Volunteer Gliding Squadron.
In 2012, the BBC reported that planning permission had been granted for a new operating base within the Nostell Priory estate for the Yorkshire Air Ambulance. The new site, including a hangar and aircrew accommodation, became operational in 2013. It replaced the facility at Leeds Bradford Airport.
One helicopter (formerly Helimed 99, registration G-SASH) was based at a hangar at Leeds Bradford Airport (EGNM), which enabled servicing and maintenance to be carried out overnight, leading to even quicker response times in many parts of the county. Until 2016, the helicopter was located at Nostell Priory near Wakefield, where it had a newly renovated hangar and accommodation for crew, plus offices on site. The aircraft was then replaced by G-YAAC (Helimed 99), a brand new £6 million Airbus H145.