The Yadkin–Pee Dee River Basin (alternatively watershed or drainage basin) is a large river basin in the eastern United States, covering around 7,221 square miles, making it the second largest in the state of North Carolina. Its headwaters rise near Blowing Rock, North Carolina, and the basin drains to the Atlantic Ocean in Winyah Bay, east of Georgetown, South Carolina.
The majority of the basin is within the Piedmont geographical area of the United States, but it also drains the coastal plains of North and South Carolina, and parts of the Appalachian Mountains, in North Carolina. It is part of the larger South Atlantic-Gulf Basin.
The watershed starts in the northwestern corner of North Carolina near Blowing Rock (protruding only slightly into Carroll and Patrick counties of Virginia) and extends south by southeast, crossing the south central border into South Carolina, with slightly more than half of the watershed in North Carolina. It is the second largest in the state.
The basin covers an area approximately 433 miles long and includes 5,862 miles of streams and rivers, 22,988 acres of lakes and has an area of about 7,221 square miles. Over 22,988 acres of the basin is covered by lakes. The basin is home to 93 separate municipalities, in 21 counties with an estimated population of 1,463,535 (2000 U.S. Census).
The basin covers a number of geographical areas, starting at the Appalachian Mountains and the North Carolina Foothills continuing through the central Piedmont area, into the Sandhills region and Coastal Plains before finally exiting into the Atlantic Ocean at Winyah Bay.