Xiaowei Zhuang
| Xiaowei Zhuang | |
|---|---|
| Native name | 庄小威 |
| Born | January 21, 1972 |
| Fields | Biophysics |
| Institutions |
Harvard University Howard Hughes Medical Institute |
| Education |
Suzhou High School University of Science and Technology of China University of California, Berkeley |
| Notable awards | MacArthur Fellows Program, ACS Award in Pure Chemistry, Max Delbruck Prize, Sackler Prize, NAS Award in Molecular Biology |
Xiaowei Zhuang (simplified Chinese: 庄小威; traditional Chinese: 莊小威) (b. January, 1972) is a Chinese-American biophysicist, and the David B. Arnold Jr. Professor of Science, Professor of Chemistry and Chemical Biology and Professor of Physics at Harvard University, and an Investigator at the Howard Hughes Medical Institute. Xiaowei Zhuang is best known for her work in the development of , a super-resolution fluorescence microscopy method, and the discoveries of novel cellular structures using STORM.
Zhuang graduated from the USTC with a B.S. in Physics in 1991. She obtained her Ph.D. in Physics from the University of California, Berkeley in 1996 and conducted her thesis research under the supervision of Dr. Yuen-Ron Shen. In 1997-2001, she was a Chodorow Postdoctoral Fellow in the laboratory of Dr. Steven Chu at Stanford University. She started her faculty position in the Department of Chemistry and Chemical Biology and Department of Physics at Harvard University in 2001.
Zhuang’s laboratory invented , a single-molecule-based super-resolution fluorescence microscopy method. The Zhuang laboratory demonstrated three-dimensional super-resolution imaging with STORM. The Zhuang laboratory also discovered several photoswitchable dye molecules that enabled STORM imaging and demonstrated live-cell STORM imaging.
Using STORM, Zhuang and colleagues have studied a variety of biological system, ranging from single-cell organisms to complex brain tissues. These studies led to the discovery of novel cellular structures, such as the periodic membrane skeletons in the axons of neurons and provided insights into many other cellular structures.
The Zhuang laboratory invented a single-cell transcriptome imaging method, MERFISH (multiplexed error-robust fluorescence in situ hybridization), which allows numerous RNA species to be imaged and quantified in single cells in their native context. Zhuang and colleagues used single-molecule FRET to study biomolecules and molecular complexes and developed single-virus tracking methods to study virus-cell interactions.
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