Wurtz-Fittig reaction

Wurtz–Fittig reaction
Named after	Charles-Adolphe Wurtz Wilhelm Rudolph Fittig
Reaction type	Coupling reaction
Identifiers
Organic Chemistry Portal	wurtz-fittig-reaction

The Wurtz–Fittig reaction is the chemical reaction of aryl halides with alkyl halides and sodium metal in the presence of dry ether to give substituted aromatic compounds.Charles-Adolphe Wurtz reported what is now known as the Wurtz reaction in 1855, involving the formation of a new carbon-carbon bond by coupling two alkyl halides. Work by Rudolph Fittig in the 1860s extended the approach to the coupling of an alkyl halide with an aryl halide. This modification of the Wurtz reaction is considered a separate process and is named for both scientists.

The reaction works best for forming asymmetrical products if the halide reactants are somehow separate in their relative chemical reactivities. One way to accomplish this is to form the reactants with halogens of different periods. Typically the alkyl halide is made more reactive than the aryl halide, increasing the probability that the alkyl halide will form the organosodium bond first and thus act more effectively as a nucleophile toward the aryl halide. Typically the reaction is used for the alkylation of aryl halides; however, with the use of ultrasound the reaction can also be made useful for the production of biphenyl compounds.

The mechanism of the reaction involves the formation of alkyl and aryl radical species which combine to form the new carbon-carbon bond.

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