"Work from Home" is a song recorded by American girl group Fifth Harmony featuring rapper and singer Ty Dolla Sign. It was released on February 26, 2016, as the lead single from the group's second studio album, 7/27 (2016). "Work from Home" was written by Joshua Coleman, Jude Demorest, Tyrone Griffin, Jr., Alexander Izquierdo, and Brian Lee.

The song debuted at number 12 on the Billboard Hot 100 with 88,000 downloads sold, and reached number 4 in its thirteenth week, becoming their highest charting single in the United States, surpassing "Worth It", which peaked at number 12. "Work from Home" also became the first top-five single in the country by a girl group in ten years, following the September 2006 peak of "Buttons" by The Pussycat Dolls at number 3. Among national airplay charts, the song topped both the Mainstream Top 40 and Rhythmic Songs. As of October 2016, the single has sold 1.3 million copies in the United States.

Internationally, "Work from Home" topped the charts in New Zealand and the Netherlands, while peaking within the top ten of the charts in twenty-two other countries. It became their highest-charting single in Australia, Denmark, Canada, Germany and the United Kingdom. Since its release, the song has received several certifications, including quadruple platinum in Australia and Canada, and triple platinum in the United States and Sweden. "Work from Home" won the award for Best Collaboration at 2016 MTV Video Music Awards. Its music video reached one billion views in October 2016.

Fifth Harmony announced the song's title on February 24, 2016. The song was originally titled "Work", but had to be re-titled "Work from Home" to avoid confusion with Rihanna's song of the same name, which was released a month prior. The track premiered on February 26, 2016 on the Elvis Duran and the Morning Show, and it was released along with the pre-order of the album. It was serviced to contemporary hit radio in the United States on March 1, 2016. While talking about how the collaboration with Ty Dolla Sign came together, group member Dinah Jane said:

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