Wilmot Vaughan, 1st Earl of Lisburne (1728 – 6 January 1800), of Trawsgoed, Cardiganshire, known as Viscount Lisburne from 1766 to 1776, was a Welsh peer and politician.
Lisburne was the son of Wilmot Vaughan, 3rd Viscount Lisburne. He was elected to the House of Commons for Cardiganshire in 1755, a seat he held until 1761 and again from 1768 to 1791 and also represented Berwick-upon-Tweed between 1765 and 1768. He served as a Lord of Trade in 1768 and as a Lord of the Admiralty from 1770 to 1782. Lisburne succeeded his father as fourth Viscount Lisburne in 1766 but as this was an Irish peerage it did not prohibit him from sitting in the House of Commons. In 1766 he was honoured when he was created Earl of Lisburne, also in the Peerage of Ireland. Apart from his political career he was also Lord Lieutenant of Cardiganshire from 1762 to his death. On 5 July 1759, he was created a DCL by Oxford.
Lord Lisburne died in January 1800 and was succeeded in his titles by his eldest son Wilmot. His second son John became the 3rd Earl. His daughter Dorothy Elizabeth married Sir Lawrence Palk, 2nd Baronet.