William Vane, 1st Viscount Vane (17 February 1682 – 20 May 1734), was a British Whig politician.
Vane was the third son of Christopher Vane, 1st Baron Barnard, and Lady Elizabeth Holles, daughter of Gilbert Holles, 3rd Earl of Clare and sister of John Holles, 1st Duke of Newcastle. He inherited a substantial fortune from his mother's family. He was returned to Parliament for County Durham in 1708, a seat he held until 1710. In 1720 he was elevated to the Peerage of Ireland as Baron Vane, of Dungannon in the County of Tyrone, and Viscount Vane. These titles did not disqualify him from sitting in the House of Commons and in 1727 he was successfully returned for Steyning. On 15 May 1734 he was elected a Knight of the Shire for Kent. However, he died suddenly only five days later.
Lord Vane married Lucy Jolliffe, daughter of Sir William Jolliffe, of Caverswall Castle, Staffordshire, in 1703. He died at Fairlawne, Shipbourne, Kent, in May 1734, and was succeeded in the viscountcy by his only surviving son, William. Lady Vane died in March 1742.