William Smith (September 7, 1727 – May 14, 1803) was the first provost of the College of Philadelphia, which became the University of Pennsylvania.
Smith was born in Aberdeen, Scotland, to Thomas and Elizabeth (Duncan) Smith. He attended the University of Aberdeen, later claiming a master's from the institution. He also held the degree of Doctor of Divinity from Aberdeen, the University of Oxford, and Trinity College, Dublin. In 1753, Smith wrote a pamphlet outlining his thoughts about education. The book fell into the hands of Benjamin Franklin and Richard Peters; as a result they asked Smith to come to Philadelphia and teach at the newly established college there (now the University of Pennsylvania).
In 1755 Smith became the first Provost (the equivalent of the modern post of university president) of the school. He held the post until 1779. Smith was an Anglican priest and together with William Moore, Smith was briefly jailed in 1758 for his criticism of the military policy in the Quaker-run colony. Indeed, during the French and Indian War, Smith published two anti-Quaker pamphlets that advocated the disenfranchisement of all Quakers—who were, at the time, the political elite in Pennsylvania. However, their pacifist beliefs made it difficult for the Quakers in government to provide funds for defense, and as a result anti-Quaker sentiment ran high, especially in the backcountry which suffered from frequent raids from Indians allied with the French. Smith's second pamphlet, A Brief View of the Conduct of Pennsylvania, For the Year 1755 (1756) actually went so far as to suggest that while one way of "ridding our Assembly of Quakers” would be to require an oath, “another way of getting rid of them" would be "by cutting their Throats.” Smith's virulent attacks on Quakers alienated him from Franklin, who was closely allied with the Pennsylvania Assembly.