Sir William Ryder (died 30 August 1611) was an English politician and Lord Mayor of London. As mayor, he played a prominent role in quashing the abortive rebellion led by the Earl of Essex.
Sir William Ryder was a member of the Haberdasher's Company, one of the livery companies of London. He served as Sheriff of the City of London in 1592, Alderman in 1595, and Lord Mayor of London for 1600 - 1601. He had two daughters: Mary, wife of Sir Thomas Lake, and Susan, wife of Sir Thomas Caesar, MP and Baron of the Exchequer. He was knighted in 1601, and died in 1611.