William Lee Antonie (24 February 1764 – 11 September 1815) was an English politician.
He was a Member of Parliament (MP) for Great Marlow from 1790 to 1796, and for Bedford from 1802 to 1812.
The grandson of Sir William Lee, Chief Justice of the King's Bench and brother of Harriet Lee, he lived at Totteridge Park, formerly in Hertfordshire and owned Colworth House near Sharnbrook in Bedfordshire.