William (Bill) Henry Danforth II (born 1926) is a retired physician, professor of medicine, and academic administrator. He was chancellor of Washington University in St. Louis from 1971 until 1995. He is the grandson of Ralston-Purina founder and St. Louis businessman William H. Danforth, and the brother of former U.S. Senator John Danforth.
William Danforth was born and grew up in St. Louis, Missouri. He attended St. Louis Country Day School, Westminster College in Fulton, Missouri, and then transferred to Princeton University, graduating in 1947. After attending Harvard Medical School and interning at Barnes Hospital in St. Louis, he served as a physician in the Navy during the Korean War. Danforth returned to St. Louis and joined the medical faculty of Washington University in 1957 as a cardiologist. This continued a connection to the University started by his grandfather, who had attended the University's Manual Arts School.
Danforth eventually took on administrative duties as vice chancellor for medical affairs at the University. He also did research in the laboratory of Nobel laureates Carl and Gerty Cori. As vice chancellor, Danforth provided counsel to Chancellor Thomas Eliot during the 1960s, when there was much student unrest. With universal support, Danforth was named Washington University's 13th Chancellor in 1971, replacing Thomas H. Eliot.
During his 24 years at the helm of the University, he is credited with bringing the University to national stature, completing several major capital campaigns, tripling the number of scholarships, increasing the endowment by an order of magnitude and establishing 70 endowed faculty chairs. Despite a rough start during the student unrest of the late 1960s and 1970s he was much loved by students and was commonly referred to as "Uncle Bill" or "Chan Dan". Chancellor Danforth maintained a clear presence during his entire tenure at Washington University and was frequently seen walking the grounds and talking with students.