William Frederick, Prince of Wied (German: Wilhelm Friedrich Hermann Otto Karl Fürst von Wied; 27 June 1872 – 18 June 1945) was a German nobleman, eldest child of William, Prince of Wied. He was an elder brother of William, Prince of Albania.

William Frederick was born at Neuwied, Kingdom of Prussia, the first child of William, Prince of Wied (1845–1907), (son of Hermann, Prince of Wied and Princess Marie of Nassau) and his wife, Princess Marie of the Netherlands (1841–1910), (daughter of Prince Frederick of the Netherlands and his wife Princess Louise of Prussia). Through his father he was descendant of George II of Great Britain. His great-grandparents were, William I of the Netherlands and Frederick William III of Prussia. He was nephew of Queen Elisabeth of Romania.

William Frederick married on 29 October 1898 in Stuttgart, Princess Pauline of Württemberg (1877–1965), only daughter of King William II of Württemberg and his first wife, Princess Marie of Waldeck and Pyrmont, daughter of George Victor, Prince of Waldeck and Pyrmont. The couple had two children:

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